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21470-01 - Lecture: Pharmacogenomics 1 CP

Semester spring semester 2024
Course frequency Every spring sem.
Lecturers Josef Gut (joseph.gut@unibas.ch, Assessor)
Content Basics Genetic polymorphisms; allelic variants; haplotypes; genotypes; phenotypes; allelic frequencies; ethnic group frequencies: Odds-ratio; positive predictive factors; negative predictive factors; genome-wide association studies; expression priofiles; etc. Pharmaco- /Toxicogenetics Pharmacogenetics in clinical setting; personalized medicine; gene-based dosie selection/adjustement; gene-based patient selection; companion tests. Expression genetics Gene expression profiles in cellular systems; gene expression profiles in preclinical animal models; gene expression proflles in the clinical staging of diseases and/or disease outcome under selected therapy regimen; realization of diagnostic tests.
Learning objectives The students understand the basic principles of pharmaco- and toxicogenomics. They also understand the concepts of pharmaco- and toxicogenetics and of expression genetics. The students understand the meaning of the correlation of genotype (or haplotype) and phenotype and corresponding tests aiming at optimizing of drug therapies. The students know a selection of important genes (and their most frequent allelic variants) which play major roles as efficacy targets for selected therapies, as targets of impaired drug disposition, and as targets for predispositions of patients for serious adverse drug effects. The students understand the meaning of expression profiles and, based on selected examples, the use of such profiles in the preclinical and clinical development of drugs as well as in the prediction of disease progression and/or therapy outcomes. The students understand the meaning of selected alleles and/or their expressed protein variants as biomarkers and their usage in as diagnostics in the approval process of new therapeutics.
Bibliography Will be announced at the beginning of the course
Comments Film and sound recordings during the course are strictly forbidden (recorders may be confiscated
Weblink Department of Pharmaceutical Sciences

 

Admission requirements Completed Bachelor degree
Language of instruction English
Use of digital media No specific media used

 

Interval Weekday Time Room
wöchentlich Wednesday 15.15-17.00 Biozentrum, Hörsaal U1.101

Dates

Date Time Room
Wednesday 28.02.2024 15.15-17.00 Biozentrum, Hörsaal U1.101
Wednesday 06.03.2024 15.15-17.00 Biozentrum, Hörsaal U1.101
Wednesday 13.03.2024 15.15-17.00 Biozentrum, Hörsaal U1.101
Wednesday 20.03.2024 15.15-17.00 Biozentrum, Hörsaal U1.101
Wednesday 27.03.2024 15.15-17.00 Pharmazentrum, Hörsaal 1
Wednesday 03.04.2024 15.15-17.00 Biozentrum, Hörsaal U1.101
Wednesday 10.04.2024 15.15-17.00 Biozentrum, Hörsaal U1.101
Wednesday 17.04.2024 15.15-17.00 --, --
Modules Electives Master Science in Pharmacy: Recommendations (Master's Studies: Science in Pharmacy)
Module Specialisation: Medical Nanosciences (Master's Studies: Nanosciences)
Module: Translating Pharmacology and Drug Safety to Humans (Master's Studies: Drug Sciences)
Assessment format continuous assessment
Assessment details Group work and online presentations (details will be communicated during the lecture).
Assessment registration/deregistration Reg.: course registration, dereg: cancel course registration
Repeat examination no repeat examination
Scale Pass / Fail
Repeated registration as often as necessary
Responsible faculty Faculty of Science, studiendekanat-philnat@unibas.ch
Offered by Departement Pharmazeutische Wissenschaften

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